Study summary

Antimicrobial efficacy of 4.2% sodium hypochlorite adjusted to pH 12, 7.5, and 6.5 in infected human root canals

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · 2009

Summary

Abstract

Objective: The purpose of this study was to determine the antimicrobial efficacy of sodium hypochlorite adjusted to pH 12, 7.5, and 6.5 in human root canals infected by Enterococcus faecalis. Study design: One hundred sixty-five human single-rooted teeth were prepared and inoculated with E. faecalis for 48 h. Teeth were divided into 3 experimental groups according to the irrigation pattern used: group 1, 4.2% NaOCl pH 12; group 2, 4.2% NaOCl pH 7.5; and group 3, 4.2% NaOCl pH 6.5. Samples from the root canals were collected, and bacterial growth was analyzed by turbidity of the culture medium. Results: None of the irrigating solutions used in this study demonstrated 100% effectiveness against E. faecalis. The antibacterial effectiveness of 4.2% NaOCl at pH 6.5 was significantly increased (P = .03) compared with 4.2% NaOCl at pH 12 (chi-squared test: P

Study details

  • Published in: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 107.2 (2009): 295-298
  • Microbes studied: Enterococcus faecalis

Source

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Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 107.2 (2009): 295-298

Conditions tested

ParameterValue
OrganismsEnterococcus spp.
Relevant sectorsDental
PublicationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2009

Reading this responsibly

Published figures are obtained under controlled conditions, usually on clean surfaces or in defined matrices. Organic load, surface condition, temperature and application coverage all affect real-world performance. Use these numbers to design a protocol, then validate it on your own site with environmental swabbing.

Applying it

Concentrations in this range are within the adjustable output of every EcoloxTech commercial system, so implementing this protocol is a settings question rather than a procurement one. Where the claim needs to sit on a registered label, see HOCl-AS200, EPA Reg. No. 101112-1.

Source

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